HF is a kind of clinical condition distinguished by functional and structural defects in the myocardium that hinder ventricular filling or blood ejection. Furthermore, a better knowledge of the molecular pathophysiology of genetically caused HF could contribute to the emergence of personalized therapeutics in future. Our findings support the understanding of the genetics aspect of HF and will provide more accurate evidence of the role of changing disease accuracy. Research sources collected from the human gene mutation and several databases revealed that numerous genes are linked to cardiomyopathy and thus explained the hereditary influence of such a condition. The selected novel genes that have been linked to human inherited cardiomyopathy play a critical role in the pathogenesis and progression of HF. The main objective of this study is to investigate heart failure and its association with cardiomyopathy with their genetic variants. There are several factors associated with the progression of HF, ranging from coronary artery disease to hypertension, of which observed the most common genetic cause to be cardiomyopathy. The incidence of HF varies depending on the definition and area, but it is calculated to be between 1 and 2% in developed countries. HF is caused by various genetic factors that are both heterogeneous and complex. Heart failure (HF) is a clinical condition distinguished by structural and functional defects in the myocardium, which genetic and environmental factors can induce.
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